Recombinant Lactococcus, a New Approach to Oral Vaccines

Background and Aim: The genus of Lactococcus lactis belonging to the Lactic Acid Bacteria (LAB) group, is a gram-positive, faculative anaerobic, non-spore-forming, non-motile bacterium. present study aimed introduce LAB, especially non-pathogenic, non-invasive, safe lactis. Accordingly, we examined previous studies concerning advantages, limitations, promotion methods, future prospects oral vaccines based on this This because it potentially promising strategy for vaccine production prevention some infectious diseases. Methods & Materials: In review article, 62 related its application in producing were collected through searching databases, such as PubMed, Google Scholar, Scopus published from 1981 2020. Ethical Considerations article was approved by Research Committee Arak University Medical Sciences with number 1396/99. Results: lactis, microorganism, widely used food industry. Live recombinant "biologic drug" orally administered one live expressing viral bacterial antigens. Conclusion: Recombinant Lactococcus-based vector can be suitable substitutes attenuated vaccines. Moreover, food-grade host manufacturing desired products human consumption over other systems. It also presents high potential delivery, mucosal methods prevent or treat certain